Panax Ginseng
Korean or Asian Ginseng, one of the most extensively studied herbal medicines in the world. The ginsenosides in Panax Ginseng modulate the HPA axis, enhance working memory, and improve sustained attention. Unlike many adaptogens, it has mildly stimulating properties and is best used for active cognitive demand rather than relaxation.
Dosage
Standard: 200-400 mg daily of extract standardized to 4-7% ginsenosides. Cereboost is a well-studied extract. Cycling is recommended (4-8 weeks on, 1-2 weeks off).
Dosages shown are for research reference only. Always consult a qualified healthcare provider.
Half-Life
4-8 hours (ginsenosides)
Administration
Oral (capsules, powder, root slices, tea). Standardized extracts preferred for consistent dosing.
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Mechanism of Action
Ginsenosides (Rb1, Rg1, Rg3, Re, and others) have diverse pharmacological actions. They modulate the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol release under stress through glucocorticoid receptor modulation. Ginsenosides inhibit acetylcholinesterase (AChE), increasing acetylcholine levels in the hippocampus and enhancing muscarinic and nicotinic receptor function. They enhance nitric oxide production via endothelial nitric oxide synthase (eNOS) for cerebral vasodilation. Rb1 and Rg1 promote BDNF and NGF expression through activation of CREB and TrkB/TrkA signaling, supporting neuroplasticity. Rg1 specifically enhances hippocampal neurogenesis via the PI3K/Akt pathway and Wnt/β-catenin signaling, and improves spatial learning in animal models. Ginsenosides may also modulate GABA-A receptors and have antioxidant properties.
Regulatory Status
Dietary supplement worldwide. Traditional medicine with thousands of years of use. Pharmacopoeia-listed in many countries. Not FDA-approved for any specific medical condition.
Risks & Safety
Common
Insomnia, headache, gastrointestinal discomfort, increased heart rate.
Serious
May interact with blood thinners, diabetes medications, and MAOIs. Estrogenic effects — caution with hormone-sensitive conditions.
Rare
Manic episodes in bipolar individuals, severe hypertension.
Compare Panax Ginseng With
Research Papers
10Published: October 14, 2003
AI Summary
The main active components of Panax ginseng are ginsenosides, which have been shown to have a variety of beneficial effects, including anti-inflammatory, antioxidant, and anticancer effects. Results of clinical research studies demonstrate that Panax ginseng may improve psychologic function, immune function, and conditions associated with diabetes.
Published: November 14, 2024
AI Summary
However, there is currently a lack of summary and analysis on the mechanism of Panax ginseng exerts its cardiovascular protective effects. This article provides a review of in vivo and in vitro pharmacological studies on Panax ginseng and its active ingredients in reducing CVDs damage.
Published: May 6, 2022
AI Summary
The use of ginseng extract showed actions on lipid homeostasis, positively regulating high-density lipoprotein, down-regulating low-density lipoprotein and triglyceride levels, and producing beneficial effects on vascular endothelial function. The use of this plant in cancer resulted in improved quality of life and mood.
Published: July 20, 2023
AI Summary
Studies have found that ginsenosides have multitarget therapeutic effects in treating dementia, such as regulation of synaptic plasticity and the cholinergic system, inhibition of Aβ aggravation and tau hyperphosphorylation, anti-neuroinflammation, anti-oxidation effects and anti-apoptosis effects.
Published: November 9, 2019
AI Summary
Several recent studies have identified an underlying role of Panax ginseng in the prevention and treatment of depression. However, the cellular and molecular mechanisms remain unclear.
Published: June 4, 2020
AI Summary
For example, Chunpoong is more highly resistant to rusty rot disease than the local Jakyungjong landrace and has a good root shape; it is highly cultivated to produce red ginseng. The Chinese cultivar Jilin Huangguo Renshen has higher ginsenoside content than its local landraces.
Published: May 24, 2022
AI Summary
COVID-19 are directly associated with hyper-activation of innate immune response that excessively produce pro-inflammatory cytokines and induce cytokine storm, leading to multi-organ-failure and significant morbidity/mortality.
Published: November 23, 2020
AI Summary
Ginseng (Panax ginseng C. Meyer), a representative Chinese herbal medicine, can improve the body's antioxidant and anti-inflammatory capacity.
Published: October 23, 2023
AI Summary
The results showed that purified Panax PDRN was effective in healing skin wounds and enhancing the skin barrier. These results were not only observed in skin cells but also in an artificial skin model (KeraSkinTM).
Published: March 12, 2022
AI Summary
Panax ginseng is a medicinal plant is a material with various pharmacological activities and research suggests that it is particularly effective in representative metabolic diseases such as hyperglycemia, hypertension, and hyperlipidemia.
Frequently Asked Questions
What is Panax Ginseng used for?
Korean or Asian Ginseng, one of the most extensively studied herbal medicines in the world. The ginsenosides in Panax Ginseng modulate the HPA axis, enhance working memory, and improve sustained attention. Unlike many adaptogens, it has mildly stimulating properties and is best used for active cognitive demand rather than relaxation.
What are the side effects of Panax Ginseng?
Common: Insomnia, headache, gastrointestinal discomfort, increased heart rate. Serious: May interact with blood thinners, diabetes medications, and MAOIs. Estrogenic effects — caution with hormone-sensitive conditions. Rare: Manic episodes in bipolar individuals, severe hypertension.
How is Panax Ginseng administered?
Panax Ginseng is administered via oral (capsules, powder, root slices, tea). standardized extracts preferred for consistent dosing..
What is the half-life of Panax Ginseng?
The half-life of Panax Ginseng is 4-8 hours (ginsenosides).
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